Research into kappa opioid receptor (KOR) agonists with attenuated central-nervous-system
side effects is a critical focus for developing productive and safe analgesics. Herein, a …

… Herein, we report an attempt to design and synthesize novel KOR agonists with an oxabicyclo[…
Synthesis of new opioid derivatives with a propellane skeleton and their pharmacologies: …

… Because aza[3.3.3]propellanes have good symmetry and compact skeleton, they … derivatives
substituted with different groups at nitrogen atoms. Therefore, we describe the preparation …

… skeleton, which possesses a useful Tyr-Gly partial structure at message sites for opioid
receptors, and designed and synthesized … a [4.4.3]propellane skeleton intermediate containing a …

… nepenthone derivative SLL-020ACP (Figure 3), an intermediate to some semisynthetic opioids,
… investigated, we designed, synthesized, and assayed a series of C7α-methyl derivatives. …

… skeleton, the N-substituent also plays an important role in opioid activities and, thus, new
14-… Pentacyclic propellane derivatives were designed and synthesized to afford agents with …

… derivatives. In the context of propellane alkaloids, the authors targeted the synthesis of … to
afford hemiaminal 104, an intermediate bearing the skeletal framework of the closely related …

… and pharmacology of Diels–Alder adducts of thebaine derivatives on opioid receptors. In …
receptor among all the series of compounds synthesized in this study. In contrast, when SLL-…

… their derivatives in pharmacology constantly drives the search for new procedures for their
construction and for the preparation … quinoline alkaloids, and its skeleton used as the design …

… of 1 as well as its 4-bromobenzoylated derivative. Different from the … of the aza[4.3.3]propellane
skeleton. (16) Based on … Synthesis of pentacyclic propellane 4 is detailed in Scheme 2…